Resuscitation of Conscious Pigs Following Hemorrhage: Blood Gas and Acid-Base Status during Fixed Volume Hemorrhage and Resuscitation with Hypertonic Saline/Dextran
Abstract
Six conscious, chronically instrumented pigs were subjected to a progressive , fixed-volume hemorrhage (37.5 ml/kg over 1 h) l and subsequent resuscitation with 7.5% NaC1/6% Dextran 70 (4ml/kg). Hemorrhage led to increases in arterial PO2, Hboz, plasma lactate base deficit, and mixed venous PC02. It led to decreases in arterial PCO2, plasma bicarbonate, buffer base, and mixed venous P02, Hb02 and pH. These effects were attributable to reduce 02 delivery, lactacidemia, hyperventilation and hemodilution. Resuscitation with hypertonic saline/dextran produced an immediate increase in cardiac output and a transfer of venous blood attributes to the arterial circulation. Resuscitation also produced an immediate decrease in arterial buffer base, an effect attributable to hemodilution. Subsequently over 4 h, most variables gradually reverted toward control levels, thereby rectifying the deleterious blood gas and acid-base disturbances produced by server hemorrhage. Keywords: partial pressure, carbon dioxide, Oxygen, oxyhemoglobin, sodium chloride.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1989
- Accession Number
- ADA207249
Entities
People
- C. A. Bossone
- Charles E.W. Wade
- J. A. Loveday
- J. P. Hannon
- M. M. Hunt
Organizations
- Letterman Army Hospital