Inhibition of Gene Expression by Alkylphosphonate Oligonucleotide Analogs with RNase-Like Activity

Abstract

The technical objectives was to synthesize an anti-viral oligonucleotide compound based on the sequence specificity of the target messenger RNA which would take advantage of the chemical instability of the m- RNA molecule. Anti-viral agents are required for control of AIDS in military populations. Oligonucleotides have been developed which, with appropriate linkers, show promising results in vitro for lowering INFECTIVITY IN CELL CULTURES. Keywords: Nucleic Acid Probes, Acquired immune deficiency syndrome, Hyman immunodeficiency virus, Immunosuppression, Virsus diseases.

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1989
Accession Number
ADA207296

Entities

People

  • Jack S. Cohen

Organizations

  • National Cancer Institute

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Acids
  • Acquired Immune Deficiency Syndrome
  • Biomedical Research
  • Biopolymers
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Culture Techniques
  • Infectious Diseases
  • Medical Personnel
  • Molecules
  • Mrna
  • Nucleic Acids
  • Ribonucleic Acids
  • Security
  • Sequences

Fields of Study

  • Biology

Readers

  • Analytical Chemistry
  • Molecular Biology and Genetics
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech