Pathophysiology of Peptide Toxins of Microcystis aeruginosa and Amanita phalloides

Abstract

Studies focused on the pathophysiology of the cyclic peptide toxin from M. aeruginosa and prophylaxis against it. The critical role of the liver as a target organ for the toxin and site of prophylaxis was established. The particular liver cell type critical to the toxin was not established. The most effective protective agents were trypan red and cyclosporine. The mechanism of action of protection was not established, but the low effective doses for each protective agent suggested great specificity in the mechanism of protection. Keywords: Antitoxins, Phytotoxins.

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Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1986
Accession Number
ADA207452

Entities

People

  • William H. Adams

Organizations

  • Brookhaven National Laboratory

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Blood
  • Blood Cells
  • Blood Proteins
  • Carbon Tetrachloride
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Culture Techniques
  • Hydroxides
  • Laboratory Animals
  • Organic Chemistry
  • Protective Agents
  • Reticuloendothelial System
  • Scintillation Counters
  • Tissues
  • Toxicity

Readers

  • Microbial Pathology
  • Molecular and Cellular Biochemistry
  • Neurotrauma and Rehabilitation Medicine.