Diazepam Pharmacokinetics in Rhesus Macaque (Macaca Mulatta)
Abstract
The purpose of this study was (1) to define the maximum serum concentration of unbound diazepam for monkeys intramuscularly administered 100 ug diazepam/kg and (2) to estimate from the literature the dose that would produce the same maximum serum concentration of unbound diazepam in man. Six rhesus monkeys were intramuscularly injected with 100 micrograms diazepam/kg in the hind limb. Blood (3, ml) was collected via an indwelling saphenous catheter immediately prior to and 5, 10, 15, 25, 40, 60, 90, 120, 180, and 240 minutes after diazepam dosing. A contract laboratory, blind of the labelling code analyzed diazepam serum concentrations by electron-capture gas chromatography and the percentage for unbound diazepam by equilibrium dialysis. Eleven open literature studies that intramuscularly administered diazepam to adult, nonpregnant humans were used to correlate administered dose to maximum serum/ plasma concentration of total diazepam.The intramuscular dose estimate from the literature to produce 177 ng/ml in man is 12.4 mg diazepam. Due to variability in the literature, the intramuscular dose for man could range from 7.1 to 20 mg diazepam.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1989
- Accession Number
- ADA207839
Entities
People
- Brian J. Lukey
- Connie R. Clark
- Kevin D. Corcoran
- Michael P. Mccluskey
Organizations
- United States Army Medical Research Institute of Chemical Defense