Pathogenesis and Treatment of Skin Lesions Caused by Sulfur Mustard: Inflammatory Mediators and Modulators Released from Organ-Cultured Inflammatory Lesions Produced in Vivo in Rabbit Skin by Sulfur Mustard

Abstract

Our research program concerns the mediators and modulators that control the development and healing of dermal sulfur mustard (SM) lesions. SM injures the epithelial cells and some cells in the deeper tissues. An acute inflammatory response follows, specifically, extravasation of serum, granulocyte and monocyte infiltration, and fibroblast activation. The epithelium dies and a crust over the ulcer forms. In human beings, blister formation is prominent. Then healing takes place. The epithelium grows in from the periphery and from the uninjured cells of the hair follicles. Fibroblasts lay down new collagen, elastin and ground substance. Finally, extensive remodeling takes place, so that the injured tissues eventually return to normal.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Feb 20, 1987
Accession Number
ADA207976

Entities

People

  • Arthur M. Dannenberg Jr.

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Biomedical And Dental Materials
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Medical Personnel
  • Organic Chemistry
  • Polymer Chemistry
  • Polymeric Films

Fields of Study

  • Biology
  • Medicine

Readers

  • Geochemistry
  • Immunology and Pathology
  • Trauma Surgery or Emergency Medicine.