Effects of Ethiofos (WR-2721) and Radiation on Monkey Visual Discrimination Performance

Abstract

WR-2721 (ethiofos) is a promising protector against radiation-induced lethality and may be useful in cancer radiotherapy (Davidson et al., 1980). However, ethiofos also produces nausea, vomiting, diarrhea, and hypotension, which implies severe behavioral consequences (Bogo et al., 1985). We studied the effects of ethiofos on behavior in monkeys and its ability to mitigate early transient incapacitation (ETI). ETI is the abrupt cessation of performance (for at least 1/min) following rapidly delivered, high doses of radiation and usually occurs 5-10 min after irradiation and lasts for 1-5 min (Bogo, 1988a). Keywords: Reprints.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA208292

Entities

People

  • A. J. Jacobs
  • C. G. Franz
  • J. F. Weiss
  • Richard W. Young
  • V. Bogo

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

DTIC Thesaurus Topics

  • Artificial Organs
  • Biomedical Research
  • Databases
  • Diarrhea
  • Discrimination
  • Gamma Rays
  • Hypotension
  • Lethality
  • Monitoring
  • Radiation
  • Radiobiology
  • Radiotherapy
  • Security
  • Stainless Steel
  • Therapy
  • Veins

Readers

  • Mathematics or Statistics
  • Nuclear and Radiation Engineering.
  • Toxicology/Environmental Toxicology