A Study of the Nephrotoxicity and Metabolism of Tetralin and Indan in Fischer 344 Rats
Abstract
Certain hydrocarbons, both acyclic and cyclic, have been shown to induce a nephrotoxic effect in male rats. There is a strong feeling that the renal damage may be related to the metabolic handling of the hydrocarbon by the animals. Both cis- and trans-decalin as well as other saturated cyclic molecules have shown a proclivity of inducing the nephrotoxicity. Tetralin and indan, because of the aromatic ring which exists as part their structures, introduces a structural difference when compared to other cyclic hydrocarbons which have produced the hyaline droplet nephrotoxicity. Male and female Fischer 344 rats were dosed intragastrically with tetralin or indan on an every other day regimen for 14 days. When compared with male control rats dosed with water, the male rat exposed to tetralin and indan exhibited increased cytoplasmic hyaline droplets in proximal convoluted tubular epithelial cells, which were indicative of toxic injury. Additionally, foci of cellular degeneration were present within proximal convoluted tubules. Exposed and control female Fischer 344 rats did not display any renal damage. Keywords: Nephrotoxicity; Cyclic compounds.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1989
- Accession Number
- ADA208588
Entities
People
- M. P. Serve'
Organizations
- Wright State University