DNA-Mediated Electron Transfer Application to 'Biochip' Development

Abstract

This project involves a study of electron transfer through double- stranded DNA to determine whether the configuration of the stacked bases in DNA can facilitate the transfer process over long distances. We will attempt to define the length, sequence, and conformation dependence of these transfer rates through DNA. The results of these experiments will hopefully lead to practical methods for deciphering as electronic signals the information content coded in DNA. To determine whether double stranded DNA can mediate the rate of electron transfer from a donor to an acceptor and whether the transfer rates are dependent on the length, base sequence and conformation of the intervening DNA. These studies will form the basis for determining whether DNA may be used as the primary matrix for designing a biological microprocessor, or 'Biochip' Keywords: Electron transfer; DNA mediated; Biochips.

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Document Details

Document Type
Technical Report
Publication Date
May 31, 1989
Accession Number
ADA208693

Entities

People

  • Pui S. Ho

Organizations

  • Oregon State University

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Alkenes
  • Arc Lamps
  • Chemical Compounds
  • Chemical Engineering
  • Chemical Synthesis
  • Chemistry
  • Contracts
  • Crystal Structure
  • Electron Donors
  • Electron Transfer
  • Electrons
  • Ethylenes
  • Military Research
  • Nucleic Acids
  • Porphyrins
  • Sequences
  • Students

Fields of Study

  • Chemistry

Readers

  • Molecular Biology and Genetics
  • Quantum Chemistry
  • Theoretical Analysis.

Technology Areas

  • Microelectronics