Evaluation of Neutralizing Antibodies to Types A, B, E, and F Botulinum Toxins in Sera from Human Recipients of Botulinum Pentavalent (ABCDE) Toxoid
Abstract
There are seven types of Clostridium botulinum, designated A-G, each type producing a pharmacologically similar but immunologically distinct neurotoxin. Immunization with botulinum toxoid has been used for over 40 years to protect laboratory personnel at risk for botulism due to contact with the neurotoxins. The botulinum toxoid currently distributed by the Centers for Disease Control is pentavalent, containing Formalin-inactivated botulinum toxins of types A, B, C, D, and E, adsorbed to aluminum phosphate. Twenty-five sera from personnel immunized with botulinum pentavalent toxoid (ABCDE) had titers of neutralizing antibodies to type A (5.7-51.6 international units (IU)/ml), type B (0.75-18 IU/ml), and to type E (0.61-10 IU/ml) botulinum toxins. Titers for one type could not be used to predict titers for another type in individuals receiving the toxoid. Cross-neutralizing antibodies to type F botulinum toxin were not detected (0.01251V/ML).
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1989
- Accession Number
- ADA208732
Entities
People
- Lynn S. Siegel
Organizations
- United States Army Medical Research Institute of Infectious Diseases