Efficacy and Mode of Action of Immune Response Modifying Compounds against Alphaviruses and Flaviviruses

Abstract

The work of the current year continues to demonstrate broad spectrum antiviral activity of immunomodulators against herpes simplex virus (HSV-2), and Banzi flavivirus, Semliki forest alphatogavirus (SFV), and Caraparu bunyavirus. There were, however, distinct patterns in the sensitivity of the virus infections to immunomodulation. HSV-2 infection was the most sensitive; therapeutic treatment with Ampligen or any of the three types of interferon (IFN) was effective even when the start of treatment was delayed until 48 hr after infection. The results indicated that IFN may be the major component in the antiviral activity of Ampligen and ABMP, and to a lesser extent, CL246, 738 and MVE-2. Anti-IFN antibody treatment, however, although effectively neutralizing poly ICLC-induced IFN, did not reduce the antiviral activity of poly ICLC. These data suggest that mechanisms in addition to IFN may be involved in the antiviral efficacy of this compound. Keywords: Banzi Virus; Caraparuvirus; Ribavirun.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1988
Accession Number
ADA208904

Entities

People

  • Angelo J. Pinto
  • Margo Brinton
  • Page S. Morahan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Infective Agents
  • Antiviral Agents
  • Blood
  • Cells
  • Cellular Structures
  • Chemistry
  • Immunomodulation
  • Infection
  • Interferon
  • Laboratory Animals
  • Lymphatic System
  • Macrophages
  • Proteins
  • Rift Valley Fever
  • Rna Virus Infections
  • Rna Viruses
  • Viruses

Fields of Study

  • Medicine

Readers

  • Virology (or Medical Virology).