Acute Oral Toxicity of Triethyleneglycol Dinitrate (TEGDN) in ICR Mice
Abstract
The acute oral toxicity of triethyleneglycol dinitrate (TEGDN) was determined in male and female ICR mice by using the oral gavage single-dose method. The median lethal dose for male mice was 2036.5 + or - 101.1 mg/kg and 1866.3 + or - 86.2 mg/kg for female mice. TEGDN produced primarily reflexive and behavioral signs. These signs included increased startle reflex, depression of grasping and righting reflexes, inactivity, tremors, jumping, twitching, convulsions, and irritability. Other clinical signs associated with TEGDN administration were squinting, hunched posture, urine stains on the abdomen, and rough or dirty hair coat. The duration of clinical signs was acute. Most animals were exhibiting signs by 2 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place TEGDN in the slightly toxic class.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1989
- Accession Number
- ADA208926
Entities
People
- Conrad Wheeler
- Don W. Korte Jr.
- Earl W. Morgan
- John R. Ryabik
Organizations
- Letterman Army Hospital