Evaluation of Euthymic Hairless Guinea Pigs (Crl:IAF(HA)BR) as an Animal Model for Vesicant Injury

Abstract

Euthymic hairless guinea pigs were compared to normal haired guinea pigs to determine whether the hairless guinea pig is a suitable animal model for studying sulfur mustard (HD) induced vesication of skin. Neat HD was applied to the skin for 30 minutes, and the exposed skin was examined at 24 and/or 48 hours post-exposure for gross, histopathologic, and/or ultrastructural lesions. The hairless guinea pig proved to be a superior animal model compared to the haired guinea pig because it was more sensitive to HD, the lesions were more readily scored, and the animal was much more convenient to use. Keywords: Guinea pigs; Hairless guinea pigs; Mustard; Vesicant.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1989
Accession Number
ADA209293

Entities

People

  • Denver D. Marlow
  • Gerald P. Jaax
  • John P. Petrali
  • Larry W. Mitcheltree
  • Millard M. Mershon

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Animals
  • Biological Sciences
  • Biomedical Research
  • Data Science
  • Electron Microscopy
  • Epidermis
  • Information Science
  • Military Research
  • Necrosis
  • Pathology
  • Rodents
  • Security
  • Skin Diseases
  • Test And Evaluation
  • Tissues
  • Vesicants

Fields of Study

  • Biology
  • Medicine

Readers

  • Analytical Chemistry
  • Canadian European Scientific Immigration and Epilepsy Clearance Studies
  • Immunology