Quantitative Classification of Known Protein Structures

Abstract

Mathematical methods have been developed for comparing the structures of proteins of arbitrary different molecular weight. A data base of structures representative of the entire Brookhaven Protein Data Bank has been assembled, containing 123 protein structures. This data base has been analyzed, using the methods developed, to determine the large-scale and local structure of the proteinome. Evidence exists for the existence of two distinct types of Beta- sheet/barrel proteins, and several types of mainly alpha-helical structures. Studies as a function of structural length scale and resolution are possible with the methods developed herein. Keywords: Molecular structure.

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Document Details

Document Type
Technical Report
Publication Date
Jun 30, 1989
Accession Number
ADA209574

Entities

People

  • Shalom R. Rackovsky

Organizations

  • University of Rochester

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Fields of Study

  • Chemistry

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  • Computational Modeling and Simulation
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