The Determination of the Acute and Repeated Oral Toxicity of Halocarbon Oil, Series 27-S
Abstract
Halocarbon 27-S (HC 27-S), a polymer of chlorotrifluoroethylene (CTFE), is used as a lubricating oil for pumps in hyperbaric chambers. Although monomeric CTFE has been shown to produce renal lesions in rats, the toxicity of CTFE polymers has not been investigated. Following a single dose of 5 g HC 27-S, no signs of toxicity were noted and no lesions observed at sacrifice 14 days following treatment. To assess the toxicity of repeated exposure to HC 27-S, three groups (n=5) of male and female rats were dosed with 2.5 g HC 27-S/kg for 7 or 21 consecutive days. Groups were sacrificed at 7, 21, and 35 days after the initial dose. Decreased water consumption and urine output were apparent in all test groups. Significant increase in fluoride excretion was noted in 24-hr urine samples collected periodically during the study. The increased fluoride burden in treated animals appeared sufficient to alter bone calcium/phosphate ratios in male but not female rats. Increased liver and kidney weights were observed in all treated rats on all assessment days. Gross liver enlargement and hepatocellular cytomegaly indicated that the liver is probably the primary target organ following repeated administration of HC 27-S. Keywords: Lubricants, Toxicity, Bone, Calcium/phosphate ratio, Chlorotrifluoroethylene, Fluoride, Halodarbon 27-S, Hepatocellular cytomegaly.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1989
- Accession Number
- ADA209589
Entities
People
- B. T. Culpepper
- C. D. Flemming
- E. R. Kinkead
- P. S. Szotak
- S. S. Henry