The Phototoxicity of Blue Light on the Functional Properties of the Retinal Pigment Epithelium

Abstract

The phototoxic effect of blue light on isolated pigment epithelium will be investigated. The emphasis will be on functional changes rather than a description of pathology. The pigment epithelium is analogous to the blood-brain barrier; therefore, the principal functions to be investigated are the integrity of the barrier system and the transport system and the transport systems known to operate in the pigment epithelium. The effects of blue light on leucine transport across the isolated bovine retinal pigment epithelium (RPE) have been continued to determine if Vitamin E and melatonin provided any protective action. Similar studies on the transport of glutamate in the retina to choroid direction were also completed.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1989
Accession Number
ADA209834

Entities

People

  • Paulter

Organizations

  • Colorado State University

Tags

Communities of Interest

  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Absorption Spectra
  • Amino Acids
  • Biological Pigments
  • Blood
  • Cells
  • Epithelial Cells
  • Epithelium
  • Glutamates
  • Molecules
  • Pilot Studies
  • Spectra
  • Tissues
  • Transport Properties
  • Transport Ships
  • Visible Spectra
  • Vitamin C
  • Vitamin E

Fields of Study

  • Biology

Readers

  • Immunology
  • Neuroscience
  • Parasitology and Pharmacology of Malaria.