Acute Oral Toxicity of Diethyleneglycol Dinitrate (DEGDN) in ICR Mice
Abstract
The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN), triethyleneglycol dinitrate (TEGDN), or trimethylolethane trinitrate (TMETN) as a replacement for nitroglycerin in munition formulations. The acute oral toxicity of diethyleneglycol dinitrate (DEGDN) was determined in male and female ICR mice by using the oral gavage single-dose method. The median lethal dose (MLD) + or - S.E. for male mice was 1395 + or - 59 mg/kc and 1321 + or - 74 mg/kg for female mice. Clinical signs produced by DEGDN included inactivity, twitching, tremors, hypertonia, squinting, hunched posture, depression of grasping and righting reflexes, rough coat, increased startle reflex, hyperactivity, moribund condition/prostration, and various stains in the perianal and abdominal areas. The duration of clinical signs was acute. Most animals were exhibiting signs by 2 hours after dosing and hac either died or cleared by 72 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place DEGDN in the slightly toxic class. Keyword: Propellants.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1989
- Accession Number
- ADA210000
Entities
People
- C. R. Wheeler
- D. W. Korte Jr.
- J. R. Ryabik
- L. D. Brown
Organizations
- Letterman Army Hospital