Perfluorodecanoic Acid and Lipid Metabolism in the Rat
Abstract
Derivatives of perfluorosulfonic and perfluorocarboxylic acids have been used in a number of industrial applications as lubricants, plasticizers, writing agents and corrosions inhibitors. Aqueous film-forming foams, used as fire extinguishants, contain mixtures of hydrocarbon and fluorocarbon surfactants (derivatized fatty acids) due to their superior surface-active properties. Studies on the effects of perfluorodecanoic acid (PFDA) on lipid metabolism in the rat after a single intraperitoneal dose (20,40, 80 mg/kg) were completed. Because PFDA treatment causes a dose-related reduction in feed intake, the response of vehicle-treated rats pair-fed to those receiving PFDA was monitored to distinguish direct effects of the perfluorinated fatty acid from those secondary to hypophagia. A reduction in the carcass content of lipid phosphorus (phospholipid) and free cholesterol in rats treated with PFDA appeared to be consequent to hypophagia, as the pair-fed animals exhibited the same attenuation. PFDA-treated rats were found to have a higher concentrations of triacylglycerols than their vehicle-treated, pair-fed counterparts. It appears PFDA treatment results in the diversion of fatty acids from oxidations towards esterifcation in the liver. Reprints.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 25, 1989
- Accession Number
- ADA210007
Entities
People
- John P. Heuvel
- Lawrence A. Menahan
- Marc J. Van Rafelghem
- Richard E. Peterson
Organizations
- University of Wisconsin Madison School of Pharmacy