Immune Response Gene Regulation of Immunity to Plasmodium Berghei Sporozoites and Circumsporozoite Protein Vaccines

Abstract

We conducted a series of experiments to define Ir gene regulation of the immune response to Plasmodium berghei sporozoites and circumsporozoite (CS) protein derived subunit vaccines. The studies demonstrated that there is no apparent genetic restriction of the capacity to develop protective immunity against a large sporozoite challenge after immunization with irradiation- attenuated P. berghei sporozoites. The results support the development of full length human CS protein vaccines to take advantage of all potential T epitopes on this protein. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
May 15, 1989
Accession Number
ADA210035

Entities

People

  • Daniel Isenbarger
  • Elana Zeltser
  • Jay A. Berzofsky
  • Mitchell Gross
  • Stephen L. Hoffman
  • W. R. Ballou
  • William R. Majarian

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Antibodies
  • Biological Factors
  • Biomedical Research
  • Blood
  • Cells
  • Dilution
  • Immunity
  • Immunization
  • Laboratory Animals
  • Lymphocytes
  • Malaria
  • Molecules
  • Proteins
  • Sporozoites
  • Vaccines

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Genetics
  • Parasitology and Pharmacology of Malaria.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology