Cloning of Plasmodium yoelii Genes Expressing Three Different Sporozoite-Specific Antigens

Abstract

Despite the rapid advances in the development of a recombinant vaccine against Plasmodium falciparum sporozoites, there is still an urgent need for a reliable rodent model to carry out complex vaccine protocols difficult to perform in primates or man. The purpose of this research was to clone the P. yoelii genes coding for sporozoite antigens that have potential as vaccine candidates in a rodent model. Keywords: Sporozoite antigens: Plasmodium yoelii: Recombinant DNA: Monoclonal antibodies: Rodent malaria: Reprints.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1989
Accession Number
ADA210040

Entities

People

  • A. Mcdermott
  • A. Wortman
  • M. Leef
  • M. Sedegah
  • P. Rogers
  • R. L. Beaudoin
  • Y. Charoenvit

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cells
  • Chemistry
  • Classification
  • Contracts
  • Deoxyribonucleic Acids
  • Elements
  • Gel Electrophoresis
  • Genetic Structures
  • Infectious Diseases
  • Maryland
  • Navy
  • Pathogenesis
  • Recombinant Dna

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular Genetics
  • Parasitology and Pharmacology of Malaria.

Technology Areas

  • Biotechnology