Experimental Treatment of Burn Victims in Field Hospitals

Abstract

A method for separating the Langerhans cell population from a mixed dermal and epidermal cell population was studied. The long term objective of this research is the design of skin grafts which are donor-independent. This research is based on the hypothesis that the Langerhans cells in the skin are the most significant contributors to the phenomenon of skin graft rejections. Several methods were considered before designing a monolayer panning technique. The panning technique, based on the highly specific affinity of the monoclonal antibody OKT-6, proved to be very effective in achieving a cell separation. Keywords: Skin anatomy; Grafting; Burns injuries; Field hospitals; Therapy; RA2.

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Document Details

Document Type
Technical Report
Publication Date
May 12, 1989
Accession Number
ADA210068

Entities

People

  • Ioannis V. Yannas

Organizations

  • Massachusetts Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anatomy
  • Animals
  • Antibodies
  • Biomedical And Dental Materials
  • Cells
  • Cellular Structures
  • Epithelial Cells
  • Health Services
  • Immune System
  • Infection
  • Laboratory Animals
  • Materials
  • Military Hospitals
  • Mononuclear Phagocyte System
  • New York
  • Rejection
  • Skin Grafts

Readers

  • Immunology
  • Systems Analysis and Design
  • Trauma Surgery or Emergency Medicine.