Methemoglobin as a Possible Antidote in Cyanide Poisoning

Abstract

The purpose of this study was to determine the effectiveness of exogenously prepared methemoglobin (Methb) as an antidote to cyanide poisoning and to determine the pharmacokinetic parameters of Methb when given by intravenous (iv) injection to rats. The effects of the administration of Methb prepared in vitro were evaluated in Sprague-Dawley rats given increasing doses of potassium cyanide (KCN). Median lethal dose (LD50) studies were conducted using KCN given by intraperitoneal (ip) injection (in 0.3-to 0.5-ml volumes) and then 2 min later administering doses of either 1000, 1500, or 25oo mg/kg of Methb iv via tail vein injection. Control rats received an equivalent volume of saline. Methemoglobin; Antidote; Pharmacokinetics; Cyanide.

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Document Details

Document Type
Technical Report
Publication Date
Dec 28, 1987
Accession Number
ADA210270

Entities

People

  • Garry W. Boswell

Tags

DTIC Thesaurus Topics

  • Albumins
  • Arteries
  • Biological Sciences
  • Blood
  • Cardiovascular System
  • Chemistry
  • Classification
  • Hemoglobin
  • Lethal Dosage
  • Medical Personnel
  • Methemoglobin
  • Poisoning
  • Potassium Cyanide
  • Regression Analysis
  • Security
  • Sodium Compounds
  • United States

Fields of Study

  • Medicine

Readers

  • Toxicology/Environmental Toxicology