Treatment of Laser-Induced Retinal Injuries
Abstract
This study investigated the effect of steroids know for their inflammatory effect on the laser-induced retinal injury. In an attempt to minimized this we studied prostaglandin E2 (PGE2), known for their mediatory-role in any inflammatory reaction, as well as changes in protein leakage. The latter is indicative of blood retinal barrier disruption. Our study revealed an enhanced PGE2 response as manifested by: 1) excessive production in vitro of PGE2 by the retina/choroid of laser-exposed eyes; 2) accumulation of both PGE2 and protein in the vitreous body to above prelaser values. Corticosteroid treatment abolished the increase in the vitreal PGE2 response, but it only partially reduced the excessive PGE2 production in vitro by retina/choroid. Treatment was effective during the first week, but later failed. The finding of the transient nature of the anti-PGE2 effect of the steroids does not necessarily point to the steroids inefficacy as anti-inflammatory agents, but rather may point to the cytoprotective nature of PGs themselves. Keywords: Suprathreshold retinal lesions, Argon lasers.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 29, 1989
- Accession Number
- ADA210284
Entities
People
- Michael Belkin
- Nava Naveh
Organizations
- Tel Aviv University