Control of Synthetic Peptide Tertiary Structure
Abstract
The proposed research seeks to design and synthesize large organic molecules possessing precisely defined geometric shapes, A capability which will make possible the design of catalysis and receptors. The approach entails the design of unnatural amino acids which, when incorporated into peptides, will enforce tertiary structure on the overall molecule. Methods are also suggested whereby transiently stable noncovalent complexes of peptides might be permanently stabilized by covalent crosslinking, leading to the concept of 'self-assembly' of large, highly ordered organic molecules. The additional possibility of assembling large structures from smaller pieces by incorporation of temporary functionality which will initially spatially orient small pieces prior to covalent assembly is suggested, a concept termed 'directed assembly.' Keywords: Molecular structure; Peptide secondary structure; Molecular design; Circular dichroism; Alpha-helix; Protein thermostabilization.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1989
- Accession Number
- ADA210339
Entities
People
- Paul B. Hopkins
Organizations
- University of Washington