Spatial Relationships between Drug Binding Sites on the Surface of the Acetylcholine Receptor
Abstract
This report is divided into three sections dealing with the development and use of fluorescent probes of the nicotinic acetylcholine receptor (AcChR). Section I summarized the purification and characterization of four mono-fluorescein cobra a-toxin derivatives. Section II deals with the use of the about derivatives to define the approximate orientation of cobra a-toxin on the acetylcholine receptor. Section III summarizes our measurements of the intersite distances between the binding sites for acetylcholine and phencyclidine on the nicotinic acetylcholine receptor.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 15, 1987
- Accession Number
- ADA210384
Entities
People
- David A. Johnson
Organizations
- University of California, Riverside