Effects of Hemorrhagic Shock on Antioxidant Enzyme Activities
Abstract
A model of hemorrhagic shock has been developed using rabbits. Rabbits are anesthetized and instrumented for comprehensive hemodynamic monitoring. Blood is withdrawn to obtain a mean arterial pressure of 35 mmHg. Retransfusion with autologous warmed shed blood is performed either 30 or 60 minutes following blood withdrawal. Tissue samples are obtained at various time intervals for determination of antioxidant enzymes activities. Results to-date indicate that superoxide dismutase activity either declines or is unchanged in plasma, myocardium, brain, large and small intestines, liver, skeletal muscle, and lung. In contrast, catalase activity is induced with substantial increases in catalase activity in each of the aforementioned tissues. These results may have important implications for understanding the pathophysiology of hemorrhagic shock and consequently, in the design of therapeutic strategies for resuscitation from hemorrhagic shock. Keywords: Hemorrhagic shock.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1989
- Accession Number
- ADA210415
Entities
People
- David C. Mayer
- Michael Artman
Organizations
- University of South Alabama