Hemostatic Activity of Chitosan in Wound Management
Abstract
Research has continued on the preparation of a hemostatic agent in the form of a lyophilized sponge composed of chitosan glutamate and collagen. Characterization of the chitosan glutamate raw material has progressed; levels of metal and amino acid contamination were determined. Work was also initiated on the vitro degradation of chitosan glutamate by lysozyme. Over 25 sample compositions of various chitosan glutamate/collagen sponges were evaluated for wet and dry strength, handling characteristics, and hemostatic activity in a rat bleeding sagittal sinus model. From these samples, two compositions were indentified for further testing. Semex Medical was identified as the manufacturer of the sponge samples. Keywords: Collagen; Chitosan glutamate; Hemostatic agents; Hemostatic sponges; Medical supplies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1989
- Accession Number
- ADA210416
Entities
People
- Terry W. Lewis
Organizations
- 3M