Effect of Glucocorticoids and Catecholamiens on Macrophage Antimicrobial Activity
Abstract
The effects of stress hormones on antibacterial and antiviral functions of resident peritoneal macrophages (MO) were determined. All studies were performed using a serum-free, chemically defined, medium, which eliminates complications which may arise as the result of hormone levels in fetal bovine serum. Restriction of herpes simplex virus type 1 (HSV-1) by resident peritoneal macrophages (MO) was essentially unaffected by the glucocorticoids, catecholamines, or isoproterenol. Phagocytosis of heat killed yeast Streptomyces cerevasiae was, however, inhibited by both dexamethose and corticosterone, but not by epinephrine or isoproterenol. The number of yeast phagocytosed per MO was inhibited by corticosterone in a dose dependent fashion. Killing of Listeria monocytogenes by resident peritoneal MO was not affected by the glucocorticoids. However, killing of L. monocytogenes by IFN or TNF/IFN activated MO (in vitro activation) appeared to be enhanced by dexamethasone. Keywords: Antiherpetics; Antiviral agents; Macrophages; Stress; Stress hormones; Glucocorticoids; Dexamethasone; Corticosterone; Catecholamines; Epinephrine; Isoproterenol; Herpes simplex virus; Listeria monocytogenes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1989
- Accession Number
- ADA210872
Entities
People
- P. S. Morahan
- Walla L. Dempsey