Clinical Pharmacology Studies. Phase 1

Abstract

In this report we summarize the work on four different oral formulations of pyridostigmine. We believe that our familiarity with the pharmacokinetics and pharmacodynamics of pyridostigmine has enhanced the validity of our observations. We also describe a study of the safety and tolerance of multiple once-daily doses of WR 6026 in a placebo-controlled, double-blind study. We are convinced that this study design was essential for correctly interpreting symptoms and abnormalities of laboratory tests that would have been impossible without a placebo control group. Keywords: Antimalarials.

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Document Details

Document Type
Technical Report
Publication Date
Apr 21, 1989
Accession Number
ADA210900

Entities

People

  • Brent G. Petty
  • David M. Kornhauser
  • Paul S. Lietman

Organizations

  • Johns Hopkins University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Chemical Synthesis
  • Chemistry
  • Contracts
  • Drug Therapy
  • Infectious Diseases
  • Institutional Review Board
  • Laboratory Tests
  • Maryland
  • Medical Personnel
  • Pharmacokinetics
  • Pharmacology
  • Schools
  • Security
  • Test Facilities
  • Universities

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology