Monocyte-Derived Interleukin 1: Effects on Aortic Contraction and Phosphatidylinositol Turnover
Abstract
Medium conditioned by silica-stimulated human peripheral blood monocytes expresses vascular suppressive activity. Rat aortic rings, after incubation in conditioned medium, exhibited compromised contraction to stimulation by norepinephrine (NE). Maximal contraction and sensitivity were both reduced in comparison to contraction and sensitivity displayed by rings after incubation in control medium. A polyvalent antibody (Ab) against human neutralized the suppressive activity in conditioned medium. Rings incubated in conditioned medium containing Ab exhibited normal maximal contraction and a partial restoration of sensitivity to NE. In contrast, incubation of rings in control medium supplemented with recombinant human I1 1 resulted in a dose dependent suppression of aortic contraction to NE that was analogous to the defects induced by monocyte conditioned medium. No significant differences in NE-stimulated hydrolysis of phosphatidylinositol (PI) were present between rings incubated in Ab-treated or untreated contractile function and that the mechanism by which I1 1 induces vascular dysfunction cannot be demonstrated to involve inhibition of NE-PI turnover. Keywords: Sepsis, Human, Rat, Vascular contraction, Phorbol.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 29, 1988
- Accession Number
- ADA210962
Entities
People
- John E. Lueders
- Thomas M. Mckenna
- Wolfgang A. Titius
Organizations
- Naval Medical Research Center