Influence of Body Weight on the Response of Fischer 344 Rats to Anthrax Lethal Toxin

Abstract

Groups of Fisher 344 rats were injected intravenously with Bacillus anthracis culture supernatants containing crude anthrax toxin. Times to death of rats given identical toxin preparations varied directly with the weight of the rats (P=0.0001). In contrast to previous reports, the data indicate that rat weight must be taking into account during in vivo assay of anthrax lethal toxin. Keywords: Anthrax; Toxin; Rats; Bacillus anthracis.

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Document Details

Document Type
Technical Report
Publication Date
Jun 12, 1989
Accession Number
ADA210998

Entities

People

  • Bruce E. Ivins
  • Gene O. Nelson
  • J. D. Ristroph

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Biological Toxins
  • Biomedical Research
  • Body Weight
  • Contrast
  • Data Science
  • Department Of Defense
  • Glutamic Acid
  • Infectious Diseases
  • Information Science
  • Intervals
  • Laboratory Animals
  • Lethality
  • Microbiology
  • Regression Analysis
  • Rodents
  • United States

Fields of Study

  • Biology

Readers

  • Military/Explosive Ordnance Disposal (EOD) Technology
  • Toxicology/Environmental Toxicology