Primary Dermal Irritation Potential of Ball Powder (Trade Name) in Rabbits

Abstract

The primary dermal irritation potential of Ball Powder (Trademark) was determined in 4 male and 4 female New Zealand White rabbits by using a modified Draize method. Two Ball Powder (Trademark) skin application sites were evaluated on each animal following a 4-hour application to closely clipped skin. Very slight erythema was observed in 1 rabbit at 1 hour after wrap removal and in 2 rabbits at 24 hours after wrap removal. All rabbits had returned to normal by 48 hours after dosing. Neither edma nor any other recognizable skin reaction was detected at any time during the 14-day observation period. Ball Powder was classified as a non-irritant under conditions of this study. Keywords: Nitroguanidine; Triple base propellants; Primary dermal irritation; Rabbits, Mammalian toxicology; Propellants.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1989
Accession Number
ADA211285

Entities

People

  • Don W. Korte Jr.
  • Larry D. Brown

Organizations

  • Letterman Army Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Classification
  • Health
  • Health Services
  • Irritants
  • Irritation
  • Materials
  • Materials Laboratories
  • Medical Personnel
  • New Zealand
  • Observation
  • Preventive Medicine
  • Propellants
  • Skin Diseases
  • Toxicology
  • Triple Base Propellants
  • United States

Readers

  • Powder metallurgy of Titanium alloys.
  • Toxicology/Environmental Toxicology