Membrane Fusion: The Role of Polyphosphatidylinositol

Abstract

We have found that the presence of the phospholipid, lysophosphatidylinositol monophosphate (LPIP) correlates positively with the fusion potential of fusogenic carrot cells. There was no correlation with the presence of phosphatidylinositol monophosphate (PIP) and phosphatidylinositol bisphosphate (PIP2) and fusion. Nor was there evidence for the need for PIP or PIP2 turnover in order for the cells to be fusion permissive. LPIP was synthesized primarily from the phosphorylation of lysophosphatidylinositol. Lysolipids were found to decrease the phosphorylation of PI and PIP suggesting a mechanism for regulating the biosynthesis of the polyphosphoinositides which are key components of the signal transduction pathway in many animal cells.

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Document Details

Document Type
Technical Report
Publication Date
Jul 24, 1989
Accession Number
ADA211289

Entities

People

  • Jeffrey J. Wheeler
  • Wendy F. Boss

Organizations

  • North Carolina State University

Tags

DTIC Thesaurus Topics

  • Anabolism
  • Cell Membrane
  • Cell Physiological Processes
  • Cells
  • Cellular Structures
  • Free Radicals
  • Identification
  • Intracellular Membranes
  • Mass Spectrometry
  • Membranes
  • Metabolism
  • Military Research
  • New York
  • North Carolina
  • Phosphorylation

Fields of Study

  • Biology

Readers

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