Dermal Sensitization Potential of Trimethylolethane Trinitrate (TMETN) in Guinea Pigs
Abstract
The Department of Defense is considering the use of either diethyleneglycol dinitrate (DEGDN), triethyleneglycol dinitrate (TEGDN), or trimethylolethane trinitrate (TMETN) as a replacement for nitroglycerin in new propellant formulations. Trimethylolethane trinitrate (TMETN) was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence of TMETN-induced sensitization was obtained in the study.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1989
- Accession Number
- ADA211295
Entities
People
- D. W. Korte
- L. D. Brown
- Yvonne C. Letellier
Organizations
- Letterman Army Hospital