Acute Oral Toxicity of Triethyleneglycol Dinitrate (TEGDN) in Sprague-Dawley Rats
Abstract
The acute oral toxicity of triethyleneglycol dinitrate (TEGDN) was determined in male and female Sprague-Dawley rats by the oral gavage single-dose method. The median lethal dose (MLD) was 1330 + or - 42 mg/kg for male rats and 1116 + or - 40 mg/kg for female rats. Clinical signs observed in this study included hunched posture, inactivity, tremors, twitching, and hypotonia. The duration of clinical signs was acute. Most animals were exhibiting signs by 2 hours after dosing and had either died or the signs had cleared by 72 hours after dosing. According to the classification scheme of Hodge and Sterner, these results place TEGDN in the slightly toxic class.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1989
- Accession Number
- ADA211313
Entities
People
- Conrad R. Wheeler
- Don W. Korte Jr.
- Gerald F. Hiatt
- Larry D. Brown
Organizations
- Letterman Army Hospital