The Role of Central Monoaminergic Systems in Arousal and Selective Attention
Abstract
The work described here is part of an ongoing set of studies aimed at characterizing the physiological actions and anatomical organization of the monoaminergic projection systems to the rat cerebral cortex, cerebellum and hypothalamus. The underlying theme of this work is that the endogenous monoamines, norepinephrine (NE) and serotonin (5-HT), serve to modulate central neuronal responsiveness to afferent synaptic inputs and by so doing participate in the cognitive process of selective attention. Individual studies conducted during the past year have investigated: 1) the adrenergic and amino acid receptor specificity of NE-induced facilitation of glutamate efficacy, 2) transmembrane effects of NE on morphologically characterized neocortical neurons and 3) the pharmacological specificity of cocaine actions on single cells in central neuronal circuits. Overall, the data provide further support for the contention that the diffusely distributed monoamine systems of the mammalian brain may enhance the performance of target neuronal circuits as a function of changing behavioral conditions.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 1989
- Accession Number
- ADA211371
Entities
People
- Barry D. Waterhouse
Organizations
- Hahnemann University Hospital