Research and Development of Human and Primate Antibodies for Immunotherapy of Viral Hemorrhagic Fever Infections

Abstract

The following report describes the methods used to produce human and primate immune globulin to Lassa fever and Argentinian hemorrhagic fever viruses and the results of the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) testing of these products. Each preparation has viral neutralizing activity and is a safe, stable, well tolerated solution suitable for intravenous injection. Included also are the experiments to demonstrate the ability of the above methods to remove Human Immunodeficiency Virus (HIV) from the raw plasma. Keywords: Areavirus; Hemorrhagic fevers; Immune plasma; Lassa fever; Immunotherapy; RA I; Antibodies; Human Immunodeficiency viruses.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1989
Accession Number
ADA211380

Entities

People

  • Richard M. Condie

Organizations

  • University of Minnesota

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Biomedical And Dental Materials
  • Blood
  • Blood Coagulation
  • Cells
  • Chemistry
  • Dengue
  • Health Services
  • Immunoglobulins
  • Lassa Fever
  • Liquid Chromatography
  • Polymeric Films
  • Rodents
  • Sodium Compounds
  • Virus Diseases
  • Viruses

Fields of Study

  • Medicine

Readers

  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology