Drug Evaluation in the Plasmodium Falciparum - Aotus Model

Abstract

Infections in Aotus trivirgatus of two strains of Plasmodium falciparum, Uganda Palo Alto (chloroquine-sensitive) or Vietnam Smith (chloroquine-resistant), or the New Guinea-Chesson strain of P. vivax, were used to assess the blood schizonticidal/curative activity of experimental antimalarial drugs. WR 245082, an acridineamine, at similar doses cured infections of chloroquinesensitive and resistant P. falciparum strains. Three 8- aminoquinolines cured trophozoite-induced infections of P. vivax. A quinoline, WR 247705, cured Uganda Palo Alto strain infections. WR 251853 was ineffective against Uganda Palo Alto parasitemias. Injection of desferrioxamine plus osmotic pump only cleared parasitemia. WR 250547, an acridinol, cured blood-induced infections of P. vivax. WR 250547 and WR 250548 administered in combination against Vietnam Smith infections a potentiating antimalarial effect was observed. WR 122455 cured all previous treatment failures and also primary infections. Sodium artesunate suppressed an Uganda Palo Alto parasitemia. Keywords: Antimalarials; Antiparasitic drugs.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1986
Accession Number
ADA211392

Entities

People

  • Richard N. Rossan

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Antimalarials
  • Biomedical Research
  • Chlorides
  • Contracts
  • Histidine
  • Implantation
  • Infection
  • Laboratory Animals
  • Malaria
  • Medical Personnel
  • New Guinea
  • Parasitic Diseases
  • Quinolines
  • Stereoisomers
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Parasitology and Pharmacology of Malaria.