Computer Support of Hemoglobin and Blood Research
Abstract
One of the troubling physiological problems for the use of concentrated hemoglobin solutions in resusitation has been fear of the consequences of extracellular hyperonconicity. Here, we will review the theoretical and some of the clinical aspects of this problem and argue that if compartmental membranes are not compromized the effects will be transient and without long term consequences. Oncotic pressure results when two fluid compartments are separated by a membrane that is impermeable to one or more solutes in either or both compartments. The potential is for solvent to move to equalize the concentration of the impermeable solutes. This potential is exactly equivalent to hydrostatic pressure, and thus we have the Starling Hypothesis that suggests that systolic pressure in the capillary (18 to 28 mmHg) is balanced by a higher concentration of protein in the plasma than in the interstitium. If the compartmental membranes are patent, not modified by toxic, inflammatory or pyrogenic reactions, it is likely that the physiology is not harmed by temporary, expansions of vascular or interstitial spaces on the order of those seen in Hb solutions. The physical forces described here can be simulated on a computer and the volume changes predicted. We can not yet predict the inotropic stress on the heart, nor with any assurance, the volume changes in the brain. To make better predictions of other organ responses, it is critical to know how the tetramer is catabolized.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 21, 1989
- Accession Number
- ADA211766
Entities
People
- Edward C. DeLand
Organizations
- University of California, Los Angeles