Estimation of the LCt50 ot Phosgene in Sheep

Abstract

Inhalation of toxic doses of phosgene results in varying degrees of pulmonary edema, often after a symptom-free period, in all species studied. The sheep is an excellent animal in which to study the development of pulmonary edema by monitoring the effluent from a catheterized caudal mediastinal lymph node. In spite of this, there appear to be no published reports of sheep having ever been exposed to phosgene. This study was undertaken as a dose-ranging study in order to permit later studies in a phosgene-exposed sheep lung lymph preparation. Accordingly, the LCt50 (24 hours) was estimated by up and down subsequent dosage selection and by moving average interpolation methods.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1989
Accession Number
ADA211874

Entities

People

  • Holcombe H. Hurt
  • James B. Nold
  • Jill R. Keeler
  • Willard J. Lennox

Organizations

  • United States Army Medical Research Institute of Chemical Defense

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Sciences
  • Biomedical Research
  • Chemical Warfare
  • Classification
  • Health
  • Instruction Manuals
  • Instructions
  • Laboratory Animals
  • Lung Diseases
  • Lymph Nodes
  • Medical Personnel
  • Monitoring
  • Nose
  • Public Health
  • Security
  • Veins

Readers

  • Cardiovascular Physiology
  • Computational Modeling and Simulation
  • Toxicology/Environmental Toxicology