Decision Tree Network for the Identification of Anticyanide Compounds
Abstract
An Anticyanide Decision Tree Network (DTN) has been designed to rapidly identify drugs which, when used on a short-term basis before expected agent exposure or immediately after exposure, will be effective in the prevention or treatment of cyanide poisoning. Three basic guidelines were used in the design of the DTN: 1) that both animal and test drug requirements be the minimum needed to provide valid comparisons of proposed therapies; 2) that proposed compounds showing no promise be eliminated from consideration as rapidly as possible; and 3) that the testing strategy provide the maximum amount of useful information possible for quantitative structure activity relationship (QSAR) studies. Although pretreatment compounds are considered more important, all compounds are scored equally depending on their activity. A series of in vitro tests will be conducted first to quickly screen for a test compound's activity and to help determine its mechanism of action before in vivo safety and efficacy tests are carried out on different animal models. Keywords: Anticyanide; Cyanide; Screening; Pretreatment; Treatment; Efficacy; In vivo; In vitro.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1989
- Accession Number
- ADA211967
Entities
People
- David E. Lenz
- Thomas Brewer
Organizations
- United States Army Medical Research Institute of Chemical Defense