Acute Oral Toxicity of Trimethylolethane Trinitrate (TMETN) in ICR Mice
Abstract
The acute oral toxicity of trimethylolethane trinitrate (TMETN) was determined in male and female ICR mice by using the oral gavage single-dose method. The MLD for male mice was 829.0 + or - 42.5 mg/kg and for female mice was 658.4 + or - 32.7 mg/kg. TMETN had a strong effect on the nervous system as indicated by the incidence of convulsions, tremors, twitching, writhing, jumping, and catalepsy. These signs were observed within 2 hours of dosing and the majority had resolved within 72 hours of dosing. Deaths were observed acutely , with 86% occurring within four hours of dosing; no deaths were observed after 24 hours. The extent of the neurotoxic component of this clinical signs profile suggests that TMETN produces pharmacological effects in addition to those routinely associated with nitrate esters. According to the classification scheme of Hodge and Steiner, these results indicate that TMETN is a slightly toxic compound. Keywords: Acute oral toxicity; Trimethylolethane trinitrate; TMETN; Mammalian toxicology; Mouse; Propellant; Munitions; Nitroglycerine substitute; Toxic tolerances; Ames mutagenicity test; Dermal toxicity.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1989
- Accession Number
- ADA211993
Entities
People
- Conrad R. Wheeler
- Don W. Korte Jr.
- Larry D. Brown
- Yvonne C. Letellier
Organizations
- Letterman Army Hospital