Antibody Responses to Liposome-Associated Antigen
Abstract
The humoral response of CAF1 mice to low doses (1- 100 micrograms) of egg albumin (EA) encapsulated in or covalently bound to the surface of liposomes was studied for three routes of administration. The liposome immunoadjuvant effect observed was found to depend on the location of the antigen, either on the liposome surface or entrapped inside the liposome, and on the number in immunizations. Following a single immunization, the highest antibody titers were elicited with liposomes having EA conjugated to their surface, regardless of the route of administration. For multiple immunization given i.v. or i.p. EA conjugated to the surface of liposomes was also superior to either free of liposome-encapsulated EA. However, the antibody response to EA to the surface of liposomes was not enhanced as compared to free EA following multiple subcutaneous immunizations. Keywords: Immunology; Reprints.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1988
- Accession Number
- ADA211995
Entities
People
- S. L. Snyder
- W. E. Vannier
Organizations
- Naval Medical Research Center