Acute Dermal Toxicity of Trimethylolethane Trinitrate (TMETN) in Rabbits
Abstract
The acute dermal toxicity of trimethylolethane trinitrate, TMETN, was evaluated in five male and five female New Zealand White rabbits. Neat TMETN (2 g/kg) was applied topically to the clipped dorsal skin surface under a semi- occlusive wrap for 24 hours. No evidence was obtained of percutaneous absorption of quantities sufficient to produce systematic toxicity or death. Seven of the rabbits exhibited very slight to slight erythema after wrap removal and all but one had cleared by 48 hours. In this animal erythema persisted for 5 days after wrap removal. These data indicate that TMETN does not produce systematic toxicity when administered by 24-hour topical application at a limit dose of 2 g/kg. Keywords: Acute dermal toxicity; TMETN; Trimethylolethane trinitrate; Rabbits; Mammalian toxicology; Propellants; Toxic tolerances.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1989
- Accession Number
- ADA212145
Entities
People
- Don W. Korte Jr.
- Earl W. Morgan
Organizations
- Letterman Army Hospital