Temperature Regulation Following Systemic Anticholinergic or Anticholinesterase Therapy

Abstract

The effect of systemic atropine (ATR, 2 mg, im) or pyridostigmine (PYR, 30 mg, oral) at rest and during moderate seated cycle exercise was evaluated in two separate protocols at an ambient temperature of 30 C. Esophageal (Tes) and mean weighted skin temperatures were measured continuously, as was forearm sweating rate, forearm blood flow (FBF, venous occlusion plethesmography) and cutaneous perfusion (SkBF, laser doppler velociometry). Whole body sweating decreased 55% (P<0.05) in ATR, while heart rate increased 30 bpm (P<0.05). ATR increased the slope (central thermosensitivity) of FBF: Tes 90% (P<0.05) compared to control. The Tes for sweating onset was increased 0.3 C (P<0.05) after ATR.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 1989
Accession Number
ADA212155

Entities

People

  • Lou A. Stephenson
  • Margaret A. Kolka

Organizations

  • United States Army Research Institute of Environmental Medicine

Tags

Communities of Interest

  • Ground and Sea Platforms
  • Sensors

DTIC Thesaurus Topics

  • Analysis Of Variance
  • Atropine
  • Blood
  • Blood Cells
  • Blood Flow
  • Blood Vessels
  • Dew Point
  • Enzyme Inhibitors
  • Heart Rate
  • Heat Loss
  • Pyridostigmine Bromide
  • Skin
  • Sweat Glands
  • Sweating
  • Vapor Pressure
  • Vasodilation
  • Water Vapor

Readers

  • Cardiovascular Physiology
  • Exercise and Sports Science.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Directed Energy
  • Directed Energy - Lasers