The Effects of Ischemia on the Cellular Levels of Cyclic Nucleotides in a Cone Dominant Retina

Abstract

A cone-dominant retina system is being developed for examining the cellular basis of ischemic damage. Normal CGMP levels in the chick retina decreases in the light. CAMP changes little. The sightless mutant rd has low levels cGMP and high levels of cAMP. Ischemic injury in both normal and rd chicks causes increased levels of both cyclic nucleotides and loss of light sensitivity. Localization of associated enzymes was also done. Keywords: Ischemia; Visual biochemistry; Cyclic nucleotides; Biological energy states; Cone; Retina, Chicks; Gallus gallus.

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Document Details

Document Type
Technical Report
Publication Date
Aug 14, 1989
Accession Number
ADA212444

Entities

People

  • Nancy R. Lee
  • Robert J. Cohen

Organizations

  • University of Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anatomy
  • Biochemistry
  • Biological Sciences
  • Brain
  • Central Nervous System
  • Chemical Compounds
  • Chemical Synthesis
  • Chemistry
  • Freezing
  • Metabolism
  • Military Research
  • Nervous System
  • New York
  • Nucleotides
  • Physiology
  • Rodents
  • Sensitivity

Fields of Study

  • Biology

Readers

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