Interaction of Malaysia Sera with Plasmodium Vivax Sporozoite Antigen
Abstract
A seroepidemiologic survey of Plasmodium vivax and Plasmodium falciparum transmission was conducted in 94 Orang Asli children and adults. The prevalence of malaria was 46% in this population, and infections due to P. vivax and P. falciparum occurred with equal frequency. Multi-species infection was common, particularly in children <10 years of age. Circumsporozoite (CS) antibodies to P. vivax were detected by ELISA, using the recombinant protein NS181V20, in sera from 53-95% of all subjects in this study. The specificity of reactivity to NS181V20 was confirmed by immunofluorescence using air-dried sporozoites. CS antibodies to P. falciparum were present in <50% of the population <30 years of age. These data support further testing of this protein as a candidate vivax vaccine. Keywords: Malaria; Vaccines; Reprints.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1988
- Accession Number
- ADA212532
Entities
People
- Don R. Davis
- Gail Folena-wasserman
- George E. Lewis
- Melinda Lee
- W. R. Ballou
Organizations
- Walter Reed Army Institute of Research