Evaluation of Stroma-Free Hemoglobin Solutions as Resuscitative Fluids for the Injured Soldier
Abstract
This study utilized three basic animal models to study the efficacy of Stroma-free Hemoglobin solutions (SFHS). The models, basically designed to evaluate cardiovascular physiology, consisted of: 1) a swine right heart bypass model detailed for myocardial evaluation, 2) a minimally instrumented exercising canine preparation to evaluate the general ability of SFHSs to support stress, and 3) an extensively instrumented exercising swine model designed to evaluate detailed hemodynamic function during stress. These studies all demonstrated the general efficacy of SFHS even with the 50% exchange used here. The SFHS was more efficacious in preserving normal physiology both at rest and exercise than a non-oxygen carrying solution (7% albumin) used for comparison. It was not possible to demonstrate a definite benefit when a SFHS modified to improved oxygen off-loading was used and compared with an unmodified SFHS having a relatively low P-50 (approximately 15 Torr). Keywords: Stroma-free hemoglobin solution; Myocardial performance; Hemodynamics; Oxygen consumption; Oxygen delivery; RA II; Blood substitutes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1988
- Accession Number
- ADA212614
Entities
People
- A. G. Greenburg
- Francis C. White
- Robert E. Mack
- William Y. Moores
Organizations
- University of California, San Diego