Effects of Atropine and Azaprophen on Matching and Detection in Rhesus Monkeys
Abstract
Azaprophen is a conformationally restricted analog of atropine. The antimuscarinic characteristics of azaprophen have been investigated in a number of in vitro preparations. For example, azaprophen has found to be substantially more potent than atropine for inhibiting carbachol-induced amylase release and for inhibiting acetylcholine-induced contractions in guinea pig ileum. In contrast, azaprophen has been reported to be slightly less potent than atropine for attenuating carbachol induced inhibition of prolactin and has been found to be both more potent and less potent than atropine for inhibiting (3H) N- methylscopolamine binding, depending on the cell line studied. In a single behavioral assay, azaprophen was slightly less potent than atropine for producing response suppression under a simple schedule of reinforcement in rats and, unlike other benzilates, failed to produce response rate increases. It has been suggested that, because of differences in the pharmacological profile azaprophen may interact with muscarinic receptors in a novel manner. Keywords: Atropine; Azaprophen; Chlinergic; Learning; Memory; Operant conditioning; Primate; Reprints.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1989
- Accession Number
- ADA212660
Entities
People
- Raymond F. Genovese
- Timothy F. Elsmore
Organizations
- Walter Reed Army Institute of Research