Performance Modification Following Alteration of Molecular Mechanisms of Thermoregulation

Abstract

The neuropharmacology of behavior related to cued discrimination tasks studied following temperature stress was the focus of this work. Prostaglandin E2 (PGE2) micro injected into the medial anterior hypothalamus/ preoptic area (MAHPOA) heat gain sites of rats that were at a normal core temperature resulted in an improvement in task performance by a decrease in error rate. The PGE2 response changes that define changes in motivation, that were elicited by changes in core temperature. THis differential response was defined as a change in an additional factor. Further studies would be required to determine the exact nature of this response and its robustness. Keywords: Pharmakokinetics; Neurophysiology; Thermoregulation; Body temperature.

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Document Details

Document Type
Technical Report
Publication Date
Aug 14, 1989
Accession Number
ADA212933

Entities

People

  • C. W. Simpson
  • Garth E. Resch

Tags

DTIC Thesaurus Topics

  • Air Force
  • Amplitude
  • Anatomy
  • Basic Training
  • Biological Sciences
  • Body Temperature
  • Brain
  • Discrimination
  • Gain
  • Heat Loss
  • Hypothalamus
  • Ketamine
  • Motivation
  • Nervous System
  • Pharmacology
  • Task Performance And Analysis
  • Training

Readers

  • Immunology and Pathology
  • Neuroscience
  • Thermal Physics or Thermal Science.