Toxicology Studies on Lewisite and Sulfur Mustard Agents: Mutagenicity of Sulfur Mustard in the Salmonella Histidine Reversion Assay
Abstract
The mutagenic potential of bis 2-chloroethyl sulfide (HD) a bifunctional sulfur mustard was evaluated in the standard plate incorporation version and the preincubation modification of the Salmonella/microsomal assay with tester strains TA97, TA98, TA100 and TA102, with and without S9 activation. HD-induced point mutations in strain TA 102 and frameshift mutations in TA97 but showed little or no mutagenicity against strains TA98 and TA100. Extensive HD- induced cell killing was observed with the excision repair deficient strains (TA100, TA98 and TA97) but not with strain TA102, which is wild-activation by Aroclor induced rat liver microsomes (S9). Keywords: Toxicity; Sulfur mustard; Mutagenicity; Ames test; RA 5. (KT)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 31, 1989
- Accession Number
- ADA213102
Entities
People
- D. L. Steward
- E. J. Sass
- L. B. Sasser
- L. K. Fritz